Treatment needs and impact of oral health screening of athletes with intellectual disability in Belgium

Background: Special Olympics Special Smiles (SOSS) is an initiative created for oral health data collection and education in oral hygiene for athletes with an intellectual disability. The aims of this study were to evaluate treatment needs of participants of Special Olympics in Belgium 2013 in comparison with those from 2008 and to assess the impact of screening and referral within the SOSS in a group of athletes who participated in two consecutive events, 2012 and 2013. Methods: Data were collected following a standardized protocol developed by the U.S. Centres for Disease Control and Prevention, Division of Oral Health. Oral hygiene habits, treatment urgency and reports of oral pain, gingival signs, sealants, untreated caries, missing and filled teeth were recorded. Data analysis of data from 2013 consisted in descriptive statistics followed by the analysis of the data by univariable and multivariable logistic regression. This data was compared with data from 2008 published by Leroy et al., 2012 using Chi square tests. Data from athletes who participated in both Special Olympics events (2012 and 2013) were compared using Exact McNemar's test and Chi-square test for homogeneity of proportions. The level of significance for all tests was set at a p-value < 0.05. Results: A total of 627 athletes with intellectual disability participated to the SOSS program in 2013, while 132 athletes met the inclusion criteria of being a participant at both SO Belgium 2012 and 2013. The prevalence of gingival signs was 44.3 % in 2013, slightly higher than in 2008 (42.4 %). The burden of untreated decay affected 27.1 % of the population showing a net increase in comparison to 2008 (20.9 %). McNemar's test and Chi-square test revealed that there were no statistically significant differences in the proportions of all compared parameters between 2012 and 2013. Conclusion: Special Olympics results from 2013 indicate a considerable unmet treatment need among Belgian Special Olympics Athletes, persistent from 2008 to 2013. Moreover, SO intervention had no impact in the oral health of athletes who participated in 2012 and 2013 events. Continuous efforts for preventive and restorative oral health care are needed for this population

Exterminate all the brutes: colonialism and racism in Joseph Conrad's heart of darkness

Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão. Programa de Pós-Graduação em Letras/Inglês e Literatura Correspondente.Esta dissertação apresenta uma análise do romance Heart of Darkness, de Joseph Conrad, utilizando-se de teorias pós-coloniais (em particular as teorias de orientalismo de Edward Said) para entender como as políticas coloniais do final do século 19 são retratadas através da mentalidade vitoriana. A aproximação do romance com documentos históricos de época revelam a ambiguidade do autor em relação às políticas de colonização ultramarina e subsequente racismo defendidas pelas metrópoles européia

Testing the universality of star formation - II. Comparing separation distributions of nearby star-forming regions and the field

We have measured the multiplicity fractions and separation distributions of seven young star-forming regions using a uniform sample of young binaries. Both the multiplicity fractions and separation distributions are similar in the different regions. A tentative decline in the multiplicity fraction with increasing stellar density is apparent, even for binary systems with separations too close (19-100au) to have been dynamically processed. The separation distributions in the different regions are statistically indistinguishable over most separation ranges, and the regions with higher densities do not exhibit a lower proportion of wide (300-620au) relative to close (62-300au) binaries as might be expected from the preferential destruction of wider pairs. Only the closest (19-100au) separation range, which would be unaffected by dynamical processing, shows a possible difference in separation distributions between different regions. The combined set of young binaries, however, shows a distinct difference when compared to field binaries, with a significant excess of close (19-100au) systems among the younger binaries. Based on both the similarities and differences between individual regions, and between all seven young regions and the field, especially over separation ranges too close to be modified by dynamical processing, we conclude that multiple star formation is not universal and, by extension, the star formation process is not universal.Comment: accepted for publication in MNRA

Graphitization of amorphous carbons: A comparative study of interatomic potentials

We perform a comparative study of six common carbon interatomic potentials: Tersoff, REBO-II, ReaxFF, EDIP, LCBOP-I and COMB3. To ensure fair comparison, all the potentials are used as implemented in the molecular dynamics package LAMMPS. Using the liquid quenching method we generate amorphous carbons at different densities, and subsequently anneal at high temperature. The amorphous carbon system provides a critical test of the transferability of the potential, while the annealing simulations illustrate the graphitization process and test bond-making and -breaking. A wide spread of behavior is seen across the six potentials, with quantities such as sp2 fraction, radial distribution function, morphology, ring statistics, and 002 reflection intensity differing considerably. While none of the potentials is perfect, some perform particularly poorly. The lack of transferability can be traced to the details of the functional form, suggesting future directions in the development of carbon potentials

Porphyrinogenic activity and ferrochelatase-inhibitory activity of sydnones in chick embryo liver cells

Abstract3-[2-(2,4,6-Trimethylphenyl)thioethyl]-4-methylsydnone was shown to be a potent porphyrinogenic agent in chick embryo liver cells. The accumulation of protoporphyrin IX was consistent with the finding that ferrochelatase activity was inhibited. 3-Benzyl-4-phenylsydnone did not inhibit ferrochelatase activity and protoporphyrin IX was found to constitute only a minor fraction of the porphyrins. These results support the idea that the porphyrinogenicity of 3-[2-(2,4,6-trimethylphenyl)thioethyl]-4-methylsydnone is due to its catalytic activation by cytochrome P-450 leading to heme alkylation and formation of N-vinylprotoporphyrin IX which inhibits ferrochelatase

Atomic-scale structure of the SrTiO3(001)-c(6x2) reconstruction: Experiments and first-principles calculations

The c(6x2) is a reconstruction of the SrTiO3(001) surface that is formed between 1050-1100oC in oxidizing annealing conditions. This work proposes a model for the atomic structure for the c(6x2) obtained through a combination of results from transmission electron diffraction, surface x-ray diffraction, direct methods analysis, computational combinational screening, and density functional theory. As it is formed at high temperatures, the surface is complex and can be described as a short-range ordered phase featuring microscopic domains composed of four main structural motifs. Additionally, non-periodic TiO2 units are present on the surface. Simulated scanning tunneling microscopy images based on the electronic structure calculations are consistent with experimental images

Initial conditions for globular clusters and assembly of the old globular cluster population of the Milky Way

Comparing N-body calculations that include primordial residual-gas expulsion with the observed properties of 20 Galactic globular clusters (GCs) for which the stellar mass function (MF) has been measured, we constrain the time-scale over which the gas of their embedded counterparts must have been removed, the star formation efficiency the progenitor cloud must have had and the strength of the tidal-field the clusters must have formed in. The three parameters determine the expansion and mass-loss during residual-gas expulsion. After applying corrections for stellar and dynamical evolution we find birth cluster masses, sizes and densities for the GC sample and the same quantities for the progenitor gas clouds. The pre-cluster cloud core masses were between 10^5-10^7 Msun and half-mass radii were typically below 1 pc and reach down to 0.2 pc. We show that the low-mass present day MF slope, initial half-mass radius and initial density of clusters correlates with cluster metallicity, unmasking metallicity as an important parameter driving cluster formation and the gas expulsion process. This work predicts that PD low-concentration clusters should have a higher binary fraction than PD high-concentration clusters. Since the oldest GCs are early residuals from the formation of the Milky Way (MW) and the derived initial conditions probe the environment in which the clusters formed, we use the results as a new tool to study the formation of the inner GC system of the Galaxy. We achieve time-resolved insight into the evolution of the pre-MW gas cloud on short time-scales (a few hundred Myr) via cluster metallicities. The results are shown to be consistent with a contracting and self-gravitating cloud in which fluctuations in the pre-MW potential grow with time. An initially relatively smooth tidal-field evolved into a grainy potential within a dynamical time-scale of the collapsing cloud.Comment: 14 pages, 12 figures, 2 tables, accepted for publication in MNRAS; former version was not the accepted version, but from an earlier stag

Short-term pretreatment with a dual 5α-reductase inhibitor before bipolar transurethral resection of the prostate (b-turp): evaluation of prostate vascularity and decreased surgical blood loss in large prostates

Objective: To investigate if short-term treatment with dutasteride (8 weeks) before bipolar transurethral resection of the prostate (B-TURP) can reduce intraoperative bleeding, as dutasteride a dual 5α-reductase inhibitor (5-ARI) blocks the conversion of testosterone into its active form dihydrotestosterone (DHT), and reduces prostate volume and prostate-specific antigen (PSA) levels, while increasing urinary flow rate. Patients and Methods: In all, 259 patients were enrolled and randomised to two groups: Group A, receiving placebo and Group B, receiving dutasteride (0.5mg daily for 8 weeks). Blood samples were taken before and after B-TURP for serum chemistry evaluation. In particular we evaluated blood parameters associated with blood loss [haemoglobin (Hb) and haematocrit (Ht)] and prostate vascularity [vascular endothelial growth factor (VEGF) immunoreactivity and microvessel density (MVD) using cluster of differentiation 34 (CD34) immunoreactivity]. Results: Total testosterone, DHT, PSA level and prostate volume were evaluated and with the exception of DHT and PSA level there was no statistically significant differences between the groups. When comparing changes in Hb and Ht between Group A and Group B before and after B-TURP, there was a statistically significant difference only in patients with large prostates of ≥50mL (ΔHb 3.86 vs 2.05g/dL and ΔHt 4.98 vs 2.64%, in Groups A and B, respectively). There was no significant difference in MVD and VEGF index in prostates of &lt;50mL, conversely in large prostates the difference become statistically significant. Conclusions: Dutasteride was able to reduce operative and perioperative bleeding only in patients with large prostates (≥50mL) that underwent B-TURP. Our findings are confirmed by Hb and Ht values reported before and after the B-TURP and reductions in the molecular markers for VEGF and CD34 in the dutasteride-treated specimens

Accessibility to oral health care for people on social assistance : a survey of social service providers from Public Welfare Centers in Flanders

Objectives: The goals of the present study were as follows: (i) to explore the characteristics of the Flemish Public Centers for Social Welfare (PCSW) concerning oral health care; (ii) to explore possible barriers experienced by people on social assistance and oral health-care providers; and (iii) to explore the accessibility of general and oral health care for people on social assistance. Methods: The data of this cross-sectional study were obtained by a survey of social service providers working in a PCSW. For this purpose, a new questionnaire was developed. The survey was validated by means of a pilot study. All 306 PCSWs in Flanders were invited to participate in this survey, of which 192 (62.7%) responded. Results: The findings demonstrate that for people on social assistance, financial limitations and low prioritisation of oral health are the main barriers to good oral health care. The study reveals that such individuals experience greater financial barriers and poorer access to a dentist than to a general medical practitioner. The study also reveals that dentists report financial concerns and administrative burdens as the main barriers in treating this subgroup. The responses of PCSWs demonstrate that local dentists are reluctant to treat this subgroup. Conclusion: Additional efforts are needed to improve the accessibility of oral health care for people on social assistance. Recommended improvements at the organisational level could improve increased education to target the population on the importance of oral health care. Administrative burden and financial concerns of the providers also need to be addressed to decrease their reluctance to work with those on social assistance

Recent advances on IMF research

Here I discuss recent work on brown dwarfs, massive stars and the IMF in general. The stellar IMF can be well described by an invariant two-part power law in present-day star-formation events within the Local Group of galaxies. It is nearly identical in shape to the pre-stellar core mass function. The majority of brown dwarfs follow a separate IMF. Evidence from globular clusters and ultra-compact dwarf galaxies has emerged that IMFs may have been top heavy depending on the star-formation rate density. The IGIMF then ranges from bottom heavy at low galaxy-wide star formation rates to being top-heavy in galaxy-scale star bursts.Comment: 6 pages, LaTeX, to appear in The Labyrinth of Star Formation, 18-22 June 2012, Crete, (eds.) D. Stamatellos, S. Goodwin, and D. Ward-Thompson, Springer, in press; replaced version: very minor corrections plus the addition of reference Smith & Lucey (2013) on the bottom-heavy IMF in elliptical galaxie